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Erasmus MC - PhD researcher - genetic modifiers in rare kidney disease Start your PhD in an international research project at the interface of genetics, clinical medicine and fundamental research. - Closing date 01-09-2026 - 3794 - 32 - 36 hours - Research university - Research & Education - Closing date 01-09-2026 - 3794 Job description As a PhD candidate/physician-scientist, you will investigate the genetic factors that explain why one patient with hereditary cystic kidney disease develops kidney failure at a young age, while a sibling carrying the same disease-causing mutation maintains stable kidney function well into later life. Your research will contribute to the development of personalized prediction and treatment strategies for hereditary kidney diseases. Read more about the project on Amazing Erasmus MC . You will contribute to a unique international research project combining genomics, bioinformatics, and advanced laboratory techniques. You will work with an international cohort of sibling pairs with highly discordant disease trajectories. Using whole-genome sequencing, you will identify genetic variants that influence disease progression. These findings will subsequently be validated in two independent patient cohorts and functionally investigated using patient-derived kidney organoids (mini-kidneys). Your work will include the collection and analysis of clinical and genetic data, performing bioinformatics analyses, designing and conducting laboratory experiments, and presenting research findings. You will work closely with nephrologists, clinical geneticists, biologists, pathologists, and other physician-scientists and researchers within a European consortium. During your PhD, you will receive intensive supervision from Dr Mahdi Salih and Prof. Ewout Hoorn . There will be ample opportunities to attend courses, participate in international conferences, and collaborate with leading research groups. You will dev...
How to apply
CV with attached letter,Online application form,Telephone
Contact: Dr Mahdi Salih | Tel: +31626139680 | Email: [email removed]
