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Importance:Prematureovarianinsufficiency(POI)affects1-4%ofwomenunder40yearsofage,resultingininfertility,hypoestrogenism,andelevatedrisksofosteoporosis,cardiovasculardisease,andprematuremortality.Conventionaltreatments,includinghormonereplacementtherapyanddonor-oocyteIVF,providesymptomaticreliefbutfailtorestoreintrinsicovarianfunction.Hydrogel-encapsulatedautologousstemcelltherapyrepresentsapotentiallytransformativeregenerativeapproachcapableofaddressingboththefolliculardepletionandhostilemicroenvironmentalbarriersthatunderliePOIpathophysiology.Objective:Tosystematicallyidentify,appraise,andsynthesizeevidenceontheuseofhydrogelbiomaterialsandautologousstemcelltherapies-individuallyandincombination-forovarianrejuvenationinwomenwithPOIordiminishedovarianreserve(DOR),andtoevaluatethetranslationalpotentialofhydrogel-basedstemcelldeliverysystems.EvidenceReview:AsystematicsearchwasconductedinPubMed/MEDLINE,Scopus,WebofScience(WoS),andCochraneCentralRegisterofControlledTrialsfromJanuary2014throughFebruary2026.Searchtermsincluded:"prematureovarianinsufficiency,""diminishedovarianreserve,""mesenchymalstemcells,""adipose-derivedstemcells,""umbilicalcordMSC,""menstrualblood-derivedMSCs,""hydrogel,""biomaterialscaffold,""ovarianrejuvenation,""cellencapsulation,"and"intraovariantransplantation,"combinedusingBooleanoperators.Studieswerescreenedbytwoindependentreviewersagainstpre-specifiedeligibilitycriteria.Disagreementswereresolvedbyconsensus.RiskofbiaswasassessedusingtheCochraneRiskofBiastool(RoB2)forrandomizedtrialsandROBINS-Ifornon-randomizedinterventionstudies.ThereviewadherestoPRISMA2020guidelines. (Budget: min ₹2500 INR, Jobs: Academic Writing, Article Writing, Content Writing, Medical Writing, Research, Research Writing, Scientific Writing, Technical Writing)
